Related Experiment Video
Updated: Sep 10, 2025
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Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
Published on: June 16, 2021
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Post-Translational Modifications in Mammalian Folliculogenesis and Ovarian Pathologies
Dake Chen1, Yue Feng1, Junjing Wu1
1Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Cells
|August 27, 2025
Summary
Post-translational modifications (PTMs) regulate mammalian fertility by controlling ovarian cell interactions and epigenetic remodeling. Understanding PTMs is crucial for addressing reproductive diseases like PCOS and POI.
Area of Science:
- Reproductive Biology
- Molecular Endocrinology
- Biochemistry
Background:
- Post-translational modifications (PTMs) are central to regulating follicular development and mammalian fertility.
- Dysregulation of PTMs is implicated in reproductive disorders such as polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI).
Purpose of the Study:
- To systematically review recent advances in PTMs involved in follicular development.
- To construct a comprehensive landscape of PTMs, including traditional and emerging modifications.
- To dissect PTM networks and their role in ovarian pathologies.
Main Methods:
- Systematic literature review of PTMs in follicular development.
- Analysis of molecular interaction networks of PTMs during key ovarian processes (activation, maturation, ovulation).
- Investigation of PTM dysregulation mechanisms in PCOS and POI.
Main Results:
- Synthesized traditional PTMs (phosphorylation, ubiquitination, acetylation) and emerging PTMs (lactylation, SUMOylation, ISGylation).
- Dissected PTM networks governing follicular activation, maturation, and ovulation.
- Identified common PTM dysregulation pathways contributing to hyperandrogenism in PCOS and follicular depletion in POI.
Conclusions:
- PTMs are critical regulators of ovarian function and fertility.
- Understanding PTMs provides insights into the pathogenesis of reproductive diseases.
- This review offers a theoretical basis for enhancing livestock reproduction and treating human ovarian disorders.
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