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Tissue-Resident Memory T Cells in Cancer Metastasis Control

Tyler H Montgomery1, Anuj P Master1, Zeng Jin1

  • 1Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Cells
|August 27, 2025
PubMed

Insights

Tissue-resident memory T (TRM) cells are key to controlling cancer spread. This review explores how TRM cells work in different cancers and how to use them to fight metastasis.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Tissue-resident memory T (TRM) cells are crucial for anti-cancer immunity.
  • Their specific functions in metastasis across diverse tumor types and tissues are not fully understood.

Purpose of the Study:

  • To review the mechanisms of TRM cell involvement in cancer metastasis.
  • To discuss therapeutic strategies and the potential of TRM cells as biomarkers.

Main Methods:

  • Literature review of current research on TRM cells in cancer metastasis.
  • Analysis of TRM cell seeding, retention, effector functions, and interactions with the tumor microenvironment.

Main Results:

  • TRM cells play a vital role in eliminating disseminated tumor cells.
  • Evidence suggests organ-specific differences in TRM cell-mediated immunity.
  • TRM cells interact dynamically with local stromal and myeloid cells.

Conclusions:

  • Harnessing TRM cell functions through therapies like vaccination and checkpoint modulation shows promise.
  • TRM cells may serve as valuable prognostic biomarkers for metastatic disease.
  • Further research is needed to translate TRM cell biology into effective anti-metastatic interventions.
Keywords:
cancercancer therapymetastasistissue-resident memory T (TRM) cells

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