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Published on: March 6, 2018
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Systematic Literature Review on Economic Evaluations and Health Economic Models in Metastatic Castration-Sensitive
Thanh Tu Nguyen1,2,3, David Ameyaw3,4, George Dennis Obeng3,4
1Center for Health Technology Assessment, Semmelweis University, 1091 Budapest, Hungary.
Current Oncology (Toronto, Ont.)
|August 27, 2025
Summary
This review of economic evaluations for metastatic castration-sensitive prostate cancer (mCSPC) found numerous studies. Most utilized Markov models to assess androgen deprivation therapy (ADT) combinations, comparing them to ADT alone.
Area of Science:
- Oncology
- Health Economics
- Pharmacoeconomics
Background:
- Metastatic prostate cancer (mPC) is initially sensitive to androgen deprivation therapy (ADT), termed castration-sensitive prostate cancer (mCSPC).
- Current standard of care for mCSPC involves combining ADT with androgen receptor pathway inhibitors (ARPI).
- A need exists to understand the economic landscape of mCSPC treatments.
Purpose of the Study:
- To systematically review existing literature on economic evaluations and health economic models for mCSPC.
- To identify common methodologies and interventions assessed in mCSPC economic studies.
Main Methods:
- Comprehensive literature search across Medline, Embase, and Scopus databases.
- Inclusion of peer-reviewed articles and grey literature focusing on economic evaluations in Europe and North America.
- Analysis of study methodologies, particularly the use of Markov models (cohort or partitioned survival).
Main Results:
- A substantial body of literature exists for economic evaluations in prostate cancer, including the mCSPC subgroup.
- 18 peer-reviewed articles and 10 grey literature documents were identified and included.
- The majority of included studies (n=23) employed deterministic Markov structures, primarily Markov cohort or partitioned survival models.
Conclusions:
- Economic evaluations for mCSPC interventions are widely available.
- Most studies utilize consistent methodologies, predominantly Markov models.
- Interventions evaluated include various ADT combinations, such as adding ARPI, chemotherapy, or radiation therapy.
