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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Anthropometry and the Risk of Breast Cancer in Moroccan Women: A Large Multicentric Case-Control Study
Najia Mane1,2, Najoua Lamchabbek2,3, Siham Mrah4
1Laboratory of Epidemiology and Research in Health Sciences, Pharmacy and Dental Medicine, Faculty of Medicine, Sidi Mohamed Ben Abdallah University, Fez 30070, Morocco.
Current Oncology (Toronto, Ont.)
|August 27, 2025
Summary
Adiposity indicators like waist and hip circumference increase breast cancer (BC) risk in pre- and post-menopausal Moroccan women. Body mass index (BMI) and weight at different life stages also show varied associations with BC risk depending on menopausal status.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Adiposity is a known modifiable risk factor for postmenopausal breast cancer (BC).
- The association between adiposity and premenopausal BC risk is less understood.
- Limited data exists on this relationship within the Moroccan population, particularly concerning menopausal status.
Purpose of the Study:
- To investigate the association between various adiposity indicators and breast cancer (BC) risk in Moroccan women.
- To examine potential differential relationships based on menopausal status (premenopausal vs. postmenopausal).
Main Methods:
- A multicenter case-control study conducted in Morocco (December 2019 - August 2023).
- Inclusion of 1400 incident BC cases and 1400 matched controls.
- Collection of detailed anthropometric measures and self-reported data across life stages; analysis using unconditional logistic regression.
Main Results:
- Increased waist circumference (WC) and hip circumference (HC) were linked to higher BC risk in both pre- and post-menopausal women.
- Current high body mass index (BMI) (≥30 kg/m²) was associated with increased postmenopausal BC risk.
- Weight at age 20 and 30, and young-adult BMI showed increased BC risk trends in both groups; weight gain since age 20 showed an inverse association in postmenopausal women.
Conclusions:
- Anthropometric factors demonstrate varied associations with pre- and postmenopausal breast cancer risk in Moroccan women.
- Findings highlight the importance of adiposity across different life stages in relation to BC risk.
- Further large-scale prospective studies are needed to elucidate these associations and their molecular links.
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