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Impact of Adjuvant Cemiplimab in High-Risk Cutaneous Squamous Cell Carcinoma

Annette M Lim1,2, Sandro Porceddu1,3, Danny Rischin1,2

  • 1Department of Medical Oncology, Peter MacCallum Cancer Centre, 3000 Melbourne, Australia.

Current Oncology (Toronto, Ont.)
|August 27, 2025
PubMed

Insights

Systemic therapies for advanced cutaneous squamous cell carcinoma (CSCC) were limited before anti-programmed cell death protein-1 (anti-PD1) agents like cemiplimab and pembrolizumab became available. These immunotherapies offer new treatment options for unresectable or metastatic CSCC.

Area of Science:

  • Oncology
  • Immunology
  • Dermatology

Background:

  • Cutaneous squamous cell carcinoma (CSCC) is a prevalent skin cancer globally.
  • Previously, unresectable or metastatic CSCC lacked approved systemic treatment options.
  • The emergence of immune checkpoint inhibitors has transformed treatment landscapes.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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