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Recent Advances in Aggregation-Induced Electrochemiluminescent Biosensors
Likang Zhou1, Junhao Fei1, Suping Zhang1
1College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China.
Biosensors
|August 27, 2025
Summary
Aggregation-induced emission (AIE) emitters boost electrochemiluminescence (ECL) biosensors for enhanced sensitivity and stability. This review explores AIE-enhanced ECL (AIECL) development, mechanisms, and applications in biosensing.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biotechnology
Background:
- Electrochemiluminescence (ECL) biosensors offer high sensitivity for detecting biomarkers.
- Aggregation-induced emission (AIE) phenomenon enhances luminescence upon molecular aggregation.
- Combining AIE with ECL creates AIECL systems with improved performance.
Purpose of the Study:
- To review the development of AIE-based ECL biosensors (AIECL).
- To compare AIECL with conventional ECL mechanisms and luminophores.
- To summarize AIECL applications and future trends in biosensing.
Main Methods:
- Comparative analysis of conventional ECL and AIECL mechanisms.
- Discussion of AIE luminophore design and construction strategies.
- Comprehensive review of AIECL applications in biosensing.
Main Results:
- AIE phenomenon significantly enhances ECL intensity, selectivity, and stability.
- AIECL emitters demonstrate superior performance over traditional ECL systems.
- Diverse applications of AIECL in various biosensing scenarios are highlighted.
Conclusions:
- AIECL technology represents a significant advancement in highly sensitive biosensing.
- Further research into AIECL luminophore design and application holds great promise.
- Addressing current challenges will accelerate the adoption of AIECL biosensors.
