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Updated: Sep 10, 2025

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
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Correlation of Clinical Characteristics of Meniere's Disease and Its Patient-Oriented Severity Index (MD POSI)

Josip Novaković1, Ana Barišić2, Erik Šuvak3

  • 1Department of Otorhinolaryngology, General Hospital Zabok, 49210 Bračak, Croatia.

Audiology Research
|August 27, 2025
PubMed

Insights

The Meniere

Area of Science:

  • Otolaryngology
  • Neurology
  • Quality of Life Research

Background:

  • Meniere's disease presents with vertigo, hearing loss, and tinnitus, impacting patient quality of life.
  • Quantitative diagnostic tools are lacking, making subjective assessments crucial.
  • The Meniere's Disease Patient-Oriented Symptom-Severity Index (MDPOSI) is a key quality-of-life assessment tool.

Purpose of the Study:

  • To investigate the relationship between clinical Meniere's disease characteristics and MDPOSI scores.
  • To determine if specific disease features correlate with patient-reported outcomes.

Main Methods:

  • Sixty Meniere's disease patients were analyzed.
  • Clinical variables included age, gender, disease laterality, and audiological/vestibular test results.
  • The MDPOSI questionnaire was administered to assess symptom severity and quality of life.

Main Results:

  • Spontaneous nystagmus correlated with poorer hearing thresholds and higher MDPOSI scores.
  • Speech Reception Threshold (SRT) scores were associated with specific MDPOSI subscales (Q1, Q2, Q4, Q5) and the total score.
  • Older age and the presence of spontaneous nystagmus were linked to higher overall MDPOSI scores.

Conclusions:

  • The MDPOSI questionnaire demonstrates a correlation with key clinical features of Meniere's disease.
  • MDPOSI is a valuable tool for evaluating quality of life and monitoring disease progression.
  • Findings support the use of MDPOSI in clinical practice for comprehensive Meniere's disease assessment.
Keywords:
MDPOSI questionnaireMeniere’s diseasequality of life

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