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Related Experiment Videos

[Connatal varicella embryo-fetopathy].

R König, P Gutjahr, R Kruel

    Helvetica Paediatrica Acta
    |December 1, 1985
    PubMed
    Summary

    Congenital varicella syndrome, a rare condition, can cause severe birth defects like limb hypoplasia following maternal chickenpox in early pregnancy. Early serodiagnosis and potential immunoglobulin treatment are crucial for pregnant women exposed to varicella.

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    Prenatal diagnosis·2017

    Area of Science:

    • Medical Science
    • Immunology
    • Teratology

    Background:

    • Congenital varicella embryo-fetopathy is a rare but severe condition.
    • Maternal varicella infection during pregnancy can lead to significant fetal abnormalities.

    Observation:

    • A case report details a newborn with severe cutaneous lesions, contractures, and limb hypoplasia.
    • Maternal varicella occurred at the 13th week of gestation.

    Findings:

    • Persistent low levels of complement fixation (CF) and ELISA IgG antibodies up to 18 months post-birth indicated a prenatal varicella infection.
    • The findings support the diagnosis of congenital varicella syndrome.

    Implications:

    • Pregnant women with varicella exposure require prompt serodiagnosis to determine immune status.
    • Seronegative women exposed to varicella should be considered for zoster-hyperimmunoglobulin administration to prevent or mitigate fetal effects.

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