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Interaction of MG63 Human Osteosarcoma-Derived Cells on S53P4 Bioactive Glass: An In Vitro Study.

Valentin Schmidt1, Beáta Polgár2, Vanda Ágnes Nemes1

  • 1Department of Traumatology and Hand Surgery, Faculty of Medicine, University of Pécs, Ifjúság Str. 13, H-7624 Pécs, Hungary.

Journal of Functional Biomaterials
|August 27, 2025
PubMed
Summary

S53P4 bioactive glass (BonAlive® granules) supports MG63 cell survival and proliferation, demonstrating its non-cytotoxic nature for bone defect repair. This confirms its biocompatibility for orthopedic and maxillofacial applications.

Keywords:
BonAlive® granulesMG63 osteoblast-like cellsbioactive glasship and knee prosthesismedical implants

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Orthopedic Research

Background:

  • Bioactive glasses are established materials for bone defect repair in orthopedics and maxillofacial surgery.
  • The biocompatibility of bioactive glasses is critical and depends on composition and environmental factors.

Purpose of the Study:

  • To evaluate the in vitro survival and proliferation of MG63 human osteosarcoma-derived cells on S53P4 bioactive glass (BonAlive® granules).
  • To assess the biocompatibility and non-cytotoxic properties of S53P4 bioactive glass.

Main Methods:

  • MG63 cells were cultured on non-adherent plates, tissue culture-treated plates, and S53P4 bioactive glass.
  • Cell survival and proliferation were monitored using a CCK-8 assay.
  • Microscopic visualization was employed to observe cell-material interactions.

Main Results:

  • MG63 cell proliferation was sustained on S53P4 bioactive glass over 168 hours, indicating continuous growth.
  • A significant difference in cell proliferation was observed between cells on bioactive glass and TC-treated plates (p < 0.05).
  • The sustained proliferation confirmed the non-cytotoxic nature of the S53P4 bioactive glass.

Conclusions:

  • S53P4 bioactive glass exhibits excellent biocompatibility and promotes MG63 cell survival and proliferation.
  • The material demonstrates non-cytotoxic properties, supporting its use in bone regeneration.
  • Thorough biocompatibility characterization is essential for effective application in orthopedic and maxillofacial surgery.