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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

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Published on: February 8, 2022

Patient Phenotypes Undergoing Tricuspid Transcatheter Edge-to-Edge Repair: Finding the Optimal Candidate.

Kyriakos Dimitriadis¹, Nikolaos Pyrpyris¹, Eirini Beneki^1,2

¹First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, 115 27 Athens, Greece.

Journal of Cardiovascular Development and Disease

|August 27, 2025

Summary

Tricuspid transcatheter edge-to-edge repair (TEER) improves symptoms and reduces hospitalizations for tricuspid regurgitation. Identifying optimal patient phenotypes is crucial for maximizing benefits beyond current outcomes.

Keywords:

atrial fibrillation cardiac electronic implantable device chronic kidney disease transcatheter edge-to-edge repair tricuspid regurgitation

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Area of Science:

Cardiology
Interventional Cardiology
Cardiac Surgery

Background:

Tricuspid regurgitation (TR) is linked to poor prognosis and mortality.
Transcatheter edge-to-edge repair (TEER) offers a new treatment option for TR.
Current evidence shows TEER improves symptoms and reduces heart failure hospitalizations, but not hard outcomes.

Purpose of the Study:

To review moderators of tricuspid TEER effectiveness.
To identify optimal patient phenotypes for tricuspid TEER.
To guide future clinical trial design for TR interventions.

Main Methods:

Review of existing studies and registries on tricuspid TEER.
Focus on novel anatomical criteria, right cardiac function, and renal physiology.
Analysis of patient phenotypes beyond simple anatomical assessment.

Main Results:

Tricuspid TEER demonstrates benefits in heart failure hospitalizations and quality of life.
Significant improvements in hard clinical outcomes are not consistently reported.
Further research is needed to define patient subgroups who benefit most.

Conclusions:

Tricuspid TEER is a safe and feasible option for TR management.
Selecting patients based on a comprehensive clinical assessment, including cardiac and renal function, is key.
Defining optimal patient phenotypes will enhance the efficacy of future tricuspid TEER interventions.