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Updated: Sep 10, 2025

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Electrochemically Promoted Three-Component Synthesis for the Functionalization of N-Sulfonylformamidine
Jia-Xiu Liu1, Xue-Yang Guo1, Shi-Jie Bo1
1State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
None:
A one-pot synthetic strategy was developed by using electrochemical methods to convert sulfonamides into N-sulfonylformamidines, followed by the direct functionalization of the C-H bond through Shono oxidation. Subsequently, modification was achieved by introducing azide groups via imide ions under Lewis acid catalysis, utilizing TMSN3 as the nucleophilic reagent. This strategy is compatible with a wide range of functional groups, and its utility has been demonstrated through scale-up experiments and derivatization reactions.
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