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Poly-4-Hydroxybutyrate as a Novel Biomaterial in Personalized Breast Surgery: A Systematic Review and Meta-Analysis
Joseph M Escandón1, Ajani Nugent1, Nolan S Karp2
1Department of Surgery, Wyckoff Heights Medical Center, 374 Stockholm St., New York, NY 11237, USA.
Journal of Personalized Medicine
|August 27, 2025
Summary
Poly-4-hydroxybutyrate (P4HB) scaffolds show promise in breast surgery, reducing wound complications and improving patient satisfaction in both reconstruction and aesthetic procedures. Further research is needed for long-term validation.
Area of Science:
- Biomaterials Science
- Plastic Surgery
- Regenerative Medicine
Background:
- Poly-4-hydroxybutyrate (P4HB) is an emerging scaffold material for breast surgery.
- Optimal meshes and matrices are crucial for successful breast augmentation and reconstruction.
- P4HB offers a promising alternative for various breast procedures.
Purpose of the Study:
- To evaluate the clinical application of P4HB scaffolds in breast surgery.
- To assess complication rates and surgical outcomes associated with P4HB use.
- To compare P4HB scaffold performance in reconstructive versus aesthetic breast surgery.
Main Methods:
- Systematic literature search of PubMed and ScienceDirect.
- Inclusion of clinical studies on perioperative outcomes and complications of P4HB scaffolds.
- Meta-analysis to determine complication and satisfaction rates.
Main Results:
- 13 studies analyzed (636 reconstructions, 462 aesthetic cases).
- High patient satisfaction (95.5%) reported with P4HB scaffolds.
- Significantly lower odds of wound complications (log-OR = -1.135, p = 0.003) observed.
Conclusions:
- P4HB scaffolds demonstrate potential in reducing wound complications in breast surgery.
- Favorable outcomes and high satisfaction noted in both reconstructive and aesthetic applications.
- Further research is recommended to confirm long-term efficacy and optimize surgical techniques.
