Established and Emerging Asthma Biomarkers with a Focus on Biologic Trials: A Narrative Review
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Summary
This summary is machine-generated.Biomarkers precisely characterize asthma endotypes, guiding biologic therapies. Emerging biomarkers promise more effective asthma management and remission, improving patient outcomes.
Area Of Science
- Pulmonology and Allergy
- Translational Medicine
Background
- Asthma is characterized by chronic airway inflammation and variable airflow obstruction, driven by distinct molecular endotypes.
- Biomarkers are crucial for endotype characterization, enabling the design, monitoring, and evaluation of asthma biologic therapies in clinical trials.
Purpose Of The Study
- To review the evolving role of biomarkers in understanding and treating asthma, focusing on approved biologics and novel markers.
- To highlight how biomarkers have advanced asthma research and clinical practice.
Main Methods
- Review of established and emerging biomarkers used in asthma research and clinical trials.
- Focus on biomarkers aiding in the characterization of the eosinophilic type 2 (T2) asthma endotype.
- Inclusion of biomarkers such as serum IgE, blood eosinophils, FeNO, periostin, sputum cells, TARC, eotaxin-3, EPX, CC16, and QCT imaging.
Main Results
- Established biomarkers (serum IgE, blood eosinophils, FeNO, periostin) elucidated the T2 asthma endotype.
- Emerging biomarkers (sputum cells, TARC, eotaxin-3, EPX, CC16, QCT) are increasingly utilized in clinical trials and specialized centers.
- Biomarkers are integral to evaluating the efficacy of biologic therapies and understanding asthma pathophysiology.
Conclusions
- Biomarkers are central to the advancement of asthma treatment, particularly biologic therapies.
- Continued research and application of biomarkers are paving the way for personalized asthma management.
- The ultimate goal is achieving symptom-free asthma remission without exacerbations through biomarker-guided therapies.
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