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circRNA/miRNA Networks Regulate KLF4 in Tumor Development

Raffaele Frazzi1, Enrico Farnetti1, Davide Nicoli1

  • 1Molecular Pathology Laboratory, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

Non-Coding RNA
|August 27, 2025
PubMed

Insights

Circular RNAs and miRNAs form novel regulatory axes impacting Krüppel-like factor 4 (KLF4) in cancer. These RNA interactions offer new therapeutic targets for various malignancies.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • Krüppel-like factor 4 (KLF4) is epigenetically regulated and implicated in cell reprogramming and cancer.
  • KLF4 expression correlates with tumor invasiveness and prognosis in a tissue-specific manner.
  • KLF4 plays a role in diverse and prevalent human cancers.

Purpose of the Study:

  • To investigate the interplay between circular RNAs (circRNAs), microRNAs (miRNAs), and KLF4 in cancer.
  • To elucidate the regulatory mechanisms involving circRNA/miRNA/KLF4 axes.

Main Methods:

  • Literature search on PubMed using keywords 'miRNA and KLF4 and cancer' (last 5 years) and 'circRNA and KLF4' (2013-2024).
  • Selection of relevant oncological publications.

Main Results:

  • Identification of circRNA/miRNA axes that regulate KLF4 expression.
  • circRNAs function as miRNA sponges, influencing KLF4 activity.
  • KLF4 exhibits context-dependent roles as a tumor promoter or suppressor.

Conclusions:

  • circRNA/miRNA/KLF4 axes represent a novel layer of epigenetic regulation in cancer.
  • These RNA-based modulators explain KLF4's complex regulation.
  • This axis presents potential for new therapeutic strategies targeting cancer.
Keywords:
KLF4circRNAsepigenetic regulation

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