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Updated: Sep 10, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Elucidating causal relationships between circulating inflammatory factors and aging traits: Transcriptomics and

Dong Cao¹, Xuelian Huang¹, Lifang Luo²

¹Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Annals of the New York Academy of Sciences

|August 27, 2025

Summary

This study used genetic analysis to explore the links between inflammation and aging. It found bidirectional causal relationships, with Interleukin-10 (IL10) being a key factor connecting immune responses to aging processes.

Keywords:

BWMR IL10 aging traits circulating inflammatory factors

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Area of Science:

Genetics and immunology
Aging research
Systems biology

Background:

Chronic inflammation is associated with aging, but specific causal factors are unknown.
Understanding the interplay between inflammation and aging is crucial for health span research.

Purpose of the Study:

To investigate the bidirectional causal relationships between circulating inflammatory protein genes and aging traits.
To identify specific inflammatory factors that influence aging and vice versa.

Main Methods:

Bidirectional Mendelian randomization (Bi-MR) analysis of 91 inflammatory protein genes and aging traits (telomere length, epigenetic clocks, frailty, cognition, health span).
Sensitivity analyses using MR-Egger, weighted median, Bayesian methods, and MR-RAPS.
Transcriptomic validation using GTEx, GSE236927, GSE123697, and GSE237029 datasets with CIBERSORT and weighted gene coexpression network analysis.

Main Results:

Identified 12 inflammatory factor genes with significant forward associations and 10 with reverse associations with aging traits.
Found causal links between CASP8 and health span, IL1A/CXCL10 and telomere length.
Demonstrated that telomere length causally influences Interleukin-10 (IL10) mRNA levels, with IL10 confirmed as an aging-related inflammatory gene.

Conclusions:

Provides robust genetic and transcriptomic evidence for bidirectional causal links between inflammation and aging.
Highlights IL10 as a significant molecular player mediating the relationship between immune regulation and aging biology.