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Updated: Sep 10, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Primary care patients' perspectives on CT coronary calcium scoring and exercise electrocardiography
Moniek Koopman1, Robert Willemsen2, Carine Doggen3
1Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Insights
Computed tomography coronary calcium scoring (CT-CCS) offers higher patient satisfaction and is a promising tool for detecting obstructive coronary artery disease (OCAD) in primary care settings. This diagnostic approach shows potential for improving cardiovascular risk management.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Primary Care Medicine
Background:
- Computed tomography coronary calcium scoring (CT-CCS) demonstrates superior sensitivity for detecting obstructive coronary artery disease (OCAD) compared to exercise electrocardiography (x-ECG).
- The utility of CT-CCS as an initial diagnostic test within primary care settings remains under investigation.
Purpose of the Study:
- To evaluate patient perspectives on CT-CCS versus x-ECG testing.
- To compare diagnostic outcomes, including OCAD diagnosis and initiation of cardiovascular risk management (CVRM), between the two testing modalities.
Main Methods:
- A one-year pilot study involving 38 general practitioner practices, cluster randomized to CT-CCS or x-ECG referrals for patients with atypical angina or non-specific thoracic complaints.
- Patient perspectives were assessed via questionnaire, and clinical data were collected from electronic patient records.
- Outcome measures included patient satisfaction, OCAD diagnosis rates, and CVRM initiation.
Main Results:
- CT-CCS patients reported significantly higher overall satisfaction, ease of undergoing the test, willingness to retest, and better perception of GP information compared to x-ECG patients.
- In the CT-CCS group, 24% of patients with a CT-CCS score ≥100 were diagnosed with OCAD, and 82% initiated CVRM.
- In the x-ECG group, only 4% of patients were included in CVRM, with no OCAD diagnosis.
Conclusions:
- CT-CCS is associated with greater patient satisfaction than x-ECG.
- Coronary calcium scoring emerges as a promising diagnostic tool for OCAD detection in primary care, potentially enhancing cardiovascular risk management strategies.
Background:
Computed tomography coronary calcium scoring (CT-CCS) shows higher sensitivity for obstructive coronary artery disease (OCAD) detection than exercise electrocardiography (x-ECG), but its role as initial diagnostic test in primary care remains unclear.
Objective(S):
This study assessed patients' perspectives on CT-CCS or x-ECG testing and diagnostic results.
Methods:
In this one-year pilot study, 38 general practitioner practices were included. After cluster randomisation, 19 practices were assigned to refer patients with atypical angina pectoris or non-specific thoracic complaints for CT-CCS and 19 practices were assigned to request x-ECG. Patients' management remained at the discretion of the GPs. Patients' perspectives on the diagnostic test were assessed through a questionnaire, and clinical data were collected using electronic patient records. Outcome measures included patients' perspectives, OCAD diagnosis and initiation of cardiovascular risk management (CVRM).
Results:
101 patients (25 x-ECG; 76 CT-CCS) were included. Overall, CT-CCS patients were more satisfied with the test compared to x-ECG patients (p < 0.001), found the test easier to undergo (p < 0.001), had a higher willingness to retest (p = 0.01) and better perception of the information received from the GP (p = 0.03). Four of 17 CT-CCS patients (24%) with CT-CCS ≥100 were diagnosed with OCAD, and 14 (82%) started CVRM. The only patient with a positive x-ECG out of 25 (4%) was included in CVRM but not diagnosed with OCAD.
Conclusion:
CT-CCS patients were overall more satisfied with their test than x-ECG patients. Coronary calcium scoring is a promising diagnostic tool for detecting OCAD in primary care.
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