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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Related Experiment Video

Updated: Sep 10, 2025

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
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Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

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Oxidative-Inflammatory Crosstalk and Multi-Target Natural Agents: Decoding Diabetic Vascular Complications.

Jingwen Liu1, Kexin Li1, Zixin Yi1

  • 1School of Life Science, Inner Mongolia University, Hohhot 010020, China.

Current Issues in Molecular Biology
|August 27, 2025
PubMed
Summary

Natural products offer a multi-target approach to combat diabetic vascular complications driven by oxidative stress and inflammation. Further research is needed for clinical translation of these promising natural remedies.

Keywords:
diabetes mellitusinflammationmulti-target therapynatural productsoxidative stressvascular complications

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Area of Science:

  • Biomedical Science
  • Pharmacology
  • Diabetology

Background:

  • Diabetes mellitus (DM) is a global health crisis with rising prevalence.
  • Chronic hyperglycemia leads to severe complications, particularly diabetic vascular lesions.
  • Oxidative stress and inflammation are key drivers of these vascular pathologies.

Purpose of the Study:

  • To systematically review the pathological pathways driving diabetic vascular lesions.
  • To explore the multi-target therapeutic potential of natural products in managing DM complications.
  • To identify challenges in the clinical translation of natural products.

Main Methods:

  • Systematic review of literature on diabetic vascular disease mechanisms.
  • Analysis of pathological pathways including metabolic dysregulation, mitochondrial dysfunction, ER stress, and epigenetics.
  • Evaluation of natural products' multi-target synergistic effects versus single-target synthetic drugs.

Main Results:

  • Hyperglycemia-induced oxidative stress and inflammation synergistically drive diabetic vascular lesions.
  • Multiple pathways (metabolic, mitochondrial, ER, epigenetic) converge to promote these pathologies.
  • Natural products demonstrate multi-target effects, restoring redox balance and suppressing inflammation.

Conclusions:

  • Natural products offer a promising therapeutic strategy for diabetic vascular disease due to their multi-target action.
  • They can improve vascular function and delay disease progression by modulating key pathogenic networks.
  • Rigorous mechanistic studies and validation are crucial for successful clinical translation of natural products.