The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota
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View abstract on PubMed
Summary
This summary is machine-generated.Periplaneta americana (PA) extract PA-011 promotes hair regeneration by enhancing antioxidant activity and regulating key signaling pathways. This medicinal insect extract also restores skin microbiota balance for effective hair growth.
Area Of Science
- Dermatology
- Pharmacology
- Microbiology
Background
- Alopecia affects over half the global population and is linked to psychological distress.
- Periplaneta americana (PA) extracts possess antioxidant, anti-inflammatory, and microcirculation-improving properties relevant to alopecia treatment.
Purpose Of The Study
- To investigate the efficacy and mechanisms of PA extracts in promoting hair regeneration.
- To explore the potential of PA-011 as a novel therapeutic agent for alopecia.
Main Methods
- Combined network pharmacology prediction with in vivo experiments in C57BL/6J mice.
- Utilized transcriptomics, metabolomics, RT-qPCR, and 16s rRNA sequencing to elucidate mechanisms.
- Assessed hair regrowth and skin pathology, alongside molecular and microbial analyses.
Main Results
- PA-011 significantly promoted hair regeneration in mice.
- Observed enhanced skin superoxide dismutase activity and vascular endothelial growth factor expression.
- Demonstrated modulation of the FOXO/PI3K/AKT signaling pathway and restoration of skin microbiota homeostasis.
- Accelerated the transition of hair follicles from telogen to anagen phase.
Conclusions
- PA-011 promotes hair growth through synergistic modulation of the FOXO/PI3K/AKT pathway and the skin microbiome.
- PA-011 represents a promising therapeutic candidate for alopecia requiring further clinical investigation.
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