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Injectable Poly-l-Lactic Acid for Treatment of the Infraorbital Hollowing

  • 0All authors are affiliated with the Cosmetic Laser Dermatology, A Platinum Dermatology Company, San Diego, California.
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.] +

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August 27, 2025

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August 27, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Poly-L-lactic acid (PLLA) injections effectively treat infraorbital hollowing, showing good patient satisfaction and minimal adverse events. This study confirms PLLA

Area Of Science

  • Dermatology
  • Aesthetic Medicine
  • Cosmetic Surgery

Background

  • Infraorbital hollowing is a common aesthetic concern.
  • Poly-L-lactic acid (PLLA) stimulates fibroblast activity to address volume loss.

Purpose Of The Study

  • Evaluate PLLA efficacy for infraorbital hollowing.
  • Assess safety and patient satisfaction.
  • Determine treatment outcomes via Physician Global Aesthetic Improvement Scale (PGAIS).

Main Methods

  • Retrospective chart review and patient survey.
  • Double-diluted PLLA injected subcutaneously.
  • Patient-reported satisfaction and pain scales.
  • PGAIS assessment using pre- and post-treatment photographs.

Main Results

  • 19 of 28 patients completed the survey.
  • Average satisfaction: 3.37/5; Average pain: 2.89/10.
  • Most common adverse events: bruising (21%), swelling (16%).
  • Mean PGAIS score of 2.62 indicated improvement.

Conclusions

  • PLLA injections are a safe and well-tolerated treatment for infraorbital hollowing.
  • Minimal adverse events observed.
  • Positive patient outcomes and aesthetic improvement achieved.