Related Experiment Video
Updated: Sep 10, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Risk Stratification Using Mitral INsufficiency Echocardiographic Score 2 in Dogs With Preclinical Mitral Valve
Tommaso Vezzosi1, Giovanni Grosso1, Liva Vatne2
1Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
A simplified Mitral INsufficiency Echocardiographic (MINE) score effectively stratifies cardiac risk in dogs with preclinical myxomatous mitral valve disease (MMVD). This tool helps identify "advanced B2" cases for better management.
Area of Science:
- Veterinary Cardiology
- Echocardiography
- Canine Health
Background:
- Preclinical myxomatous mitral valve disease (MMVD) lacks effective outcome-based cardiac risk stratification.
- The Mitral INsufficiency Echocardiographic (MINE) score was developed for MMVD severity classification.
Purpose of the Study:
- To validate the MINE score for cardiac risk stratification in preclinical MMVD.
- To simplify the MINE score and define "advanced B2" stage.
Main Methods:
- Retrospective, multicenter cohort study of 749 dogs with preclinical MMVD.
- Cox proportional hazards regression and Kaplan-Meier analysis were used.
- Evaluated association between MINE score and time to cardiac event.
Main Results:
- A simplified MINE score (left atrium-to-aorta ratio, left ventricular end-diastolic diameter, E-wave velocity) showed clinical effectiveness.
- Dogs with mild MMVD had significantly longer median time to cardiac event than moderate and severe cases.
- Within stage B2, severe cases experienced shorter median time to cardiac event compared to moderate and mild cases.
Conclusions:
- The simplified MINE score is clinically effective for risk stratifying preclinical MMVD.
- "Severe" stage B2 dogs can be defined as "advanced" B2, aiding clinical decision-making.
More Related Videos
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
08:31A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Related Concept Videos
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Valve Prolapse I: Introduction
Mitral Stenosis I: Introduction
Mitral Stenosis III: Medical Management