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Updated: Sep 10, 2025

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Research progress on the correlation between microbiota and endometriosis.

Jingyi Wang¹, Xiaojie Wang¹

¹Department of Gynecologic Oncology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.

European Journal of Obstetrics, Gynecology, and Reproductive Biology

|August 27, 2025

Summary

Microbiota dysbiosis, an imbalance in gut and reproductive tract microbes, is linked to endometriosis pathogenesis. Interventions targeting the microbiota offer promising new strategies for managing this inflammatory disorder.

Keywords:

Endometriosis Gut microbiota Gut-brain axis Microbiota dysbiosis Reproductive tract microbiota

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiology
Gynecology
Immunology

Background:

The human microbiota is essential for physiological functions.
Endometriosis (EMs) is a chronic inflammatory disorder characterized by ectopic endometrial tissue.
EMs causes significant pain, infertility, and psychological distress.

Purpose of the Study:

To review current research on the interaction between microbiota dysbiosis and endometriosis.
To explore the role of microbial imbalances in EMs pathogenesis.
To identify potential microbiota-targeted diagnostic and therapeutic strategies for EMs.

Main Methods:

Systematic review of existing literature.
Analysis of studies investigating gut and reproductive tract microbiota in EMs.
Synthesis of evidence on inflammatory pathways and metabolic alterations.

Main Results:

Dysbiosis in the gut and reproductive tract microbiota contributes to EMs.
Microbial imbalances can trigger local and systemic inflammation via cytokines and metabolites.
These inflammatory responses are implicated in the development and progression of EMs.

Conclusions:

Microbiota dysbiosis is a significant factor in endometriosis development.
Understanding these interactions can lead to novel diagnostic tools.
Microbiota-targeted therapies represent a promising avenue for EMs management.