Related Experiment Video
Updated: Sep 10, 2025
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
347
Weight management treatment in obesity
Miguel A Rubio-Herrera1, Sara Mera-Carreiro2
1Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IDISSC), Madrid, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Medicina Clinica
|August 27, 2025
Summary
New obesity drugs targeting the gut-brain axis offer significant weight loss, comparable to surgery. Combination therapies show promise for greater efficacy and improved health outcomes in managing this chronic disease.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Background:
- Obesity is a complex, chronic disease with significant health risks.
- The gut-brain axis plays a crucial role in appetite regulation and energy balance.
- Emerging therapies focus on nutrient-stimulated hormones to combat obesity.
Purpose of the Study:
- To review the efficacy and safety of current and investigational obesity pharmacotherapies.
- To explore the role of gut-brain axis modulating agents in weight management.
- To discuss challenges in long-term obesity treatment adherence.
Main Methods:
- Review of marketed drugs and ongoing clinical trials for obesity pharmacotherapy.
- Analysis of hormonal agents targeting the gut-brain axis, including GLP-1 receptor agonists and dual/triple agonists.
- Examination of weight loss data and safety profiles of various therapeutic agents.
Main Results:
- Glucagon-like peptide-1 (GLP-1) receptor agonists achieve 15-17% weight loss with good safety.
- Dual GLP-1/GIP receptor agonists like Tirzepatide show up to 22.5% weight loss.
- Combination therapies (e.g., Cagrisema, Retatrutide) are expected to further enhance weight loss and cardiometabolic benefits.
Conclusions:
- Second-generation obesity pharmacotherapies offer substantial weight loss, approaching surgical outcomes.
- Combination hormone therapies hold significant potential for greater weight reduction and metabolic improvement.
- Long-term treatment adherence remains a key challenge for patients and healthcare providers.
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