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Psychiatric multimorbidity in heart failure.

Kenneth E Freedland¹, Judith A Skala¹, Brian C Steinmeyer¹

¹Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

Journal of Psychosomatic Research

|August 27, 2025

Summary

This summary is machine-generated.

Psychiatric multimorbidity is common in heart failure patients, affecting 36% of those studied. This condition is linked to social determinants of health, increased stress, and other health issues.

Keywords:

Comorbidity Heart failure Mental disorders Multimorbidity Psychological Quality of life Social determinants of health Stress

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Area of Science:

Cardiology
Psychiatry
Public Health

Background:

Specific psychiatric conditions are studied in heart disease patients, but psychiatric multimorbidity is less understood.
Psychiatric multimorbidity, the co-occurrence of multiple mental health disorders, requires further investigation in cardiovascular populations.

Purpose of the Study:

To determine the prevalence of psychiatric multimorbidity in patients with heart failure (HF).
To identify factors associated with psychiatric multimorbidity in HF patients.

Main Methods:

A cross-sectional study involving 362 hospitalized heart failure patients within 30 days of discharge.
Utilized the NetSCID-5 diagnostic interview, social determinants of health (SDOH) interview, and questionnaires for perceived stress and quality of life.

Main Results:

36% of patients (130/362) had a history of two or more psychiatric disorders.
Higher psychiatric comorbidity counts correlated with younger age, greater SDOH exposure, elevated perceived stress, and chronic obstructive pulmonary disease.

Conclusions:

Psychiatric multimorbidity is prevalent in heart failure patients and linked to poorer medical and social health outcomes.
Future research on heart disease comorbidities should consider multimorbidity, and dedicated studies on psychiatric multimorbidity are necessary.