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Related Concept Videos

Conformations of Butane02:20

Conformations of Butane

14.8K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
14.8K
Conformations of Ethane and Propane02:18

Conformations of Ethane and Propane

14.5K
In an organic molecule, free rotation about the carbon-carbon single bond results in energetically different conformers of the molecule. Due to this rotation, called the internal rotation, ethane has two major conformations — staggered and eclipsed.
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered...
14.5K
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

12.2K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
12.2K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

915
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
915
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.2K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.2K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

13.0K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
13.0K

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Related Experiment Video

Updated: Sep 10, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

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A cough detection method based on the conformer-BiLSTM model.

Wenlong Xu1, Hangrui Zhang1, Chen Pan1

  • 1College of Information Engineering, China Jiliang University, Hangzhou, Zhejiang, People's Republic of China.

Biomedical Physics & Engineering Express
|August 27, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a hybrid conformer and bidirectional long short-term memory (BiLSTM) network for accurate cough sound detection. The model precisely identifies cough events, improving respiratory disease analysis.

Keywords:
conformer-bilstm modelcough detectiondeep learningmulti-head attention residual connection

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Area of Science:

  • Computational linguistics
  • Biomedical signal processing
  • Machine learning for healthcare

Background:

  • Cough detection is crucial for respiratory disease diagnosis.
  • Manual cough sound segmentation is time-consuming and subjective.
  • Real-world cough recordings present detection challenges due to environmental and device variability.

Purpose of the Study:

  • To develop an automated and accurate method for cough sound event detection.
  • To improve the efficiency and objectivity of cough analysis.
  • To address the difficulties in detecting coughs from diverse real-world audio data.

Main Methods:

  • A hybrid model combining conformer and bidirectional long short-term memory (BiLSTM) networks was proposed.
  • The BiLSTM model captured contextual information, while the conformer model extracted global features using multi-head attention residual connections.
  • The model was trained and validated on the publicly available Vocalsound dataset, comprising 500 audio files with 1928 annotated cough sounds.

Main Results:

  • The hybrid model achieved 97.22% sensitivity and 97.08% specificity on the annotated dataset.
  • In a clinical dataset evaluation, the model demonstrated 98.45% sensitivity and 92.7% specificity.
  • An average time overlap rate of 81.12% was recorded in the clinical dataset, indicating precise event localization.

Conclusions:

  • The proposed conformer-BiLSTM hybrid model offers a robust and accurate solution for automated cough sound detection.
  • This approach significantly enhances the efficiency and reliability of cough analysis in respiratory disease research.
  • The model's high performance in both public and clinical datasets suggests its potential for real-world applications in healthcare.