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Updated: Sep 10, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Extrachromosomal DNA (ecDNA) drives hepatocellular carcinoma malignancy through high-copy amplification of chromosome

Ni Zhang1, Xiangyu Zhang2, Tinghao Yan1

  • 1Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250000, China.

Cancer Letters
|August 27, 2025
PubMed

Keywords:
Circle-seqExtrachromosomal DNAExtrachromosomal circular DNAHepatocellular carcinomaPIP5K1A

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