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Testing a New Diabetes Adaptive Weight management Network (NewDAWN): A protocol for a randomised controlled trial
Nicola Guess1, Sarah Wane1, Charlotte Albury1
1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, United Kingdom.
Contemporary Clinical Trials
|August 27, 2025
Summary
Offering diverse weight loss programs, including the NewDAWN service alongside the NHS Path to Remission (PtR), may boost type 2 diabetes (T2D) remission rates. This study compares uptake and persistence between the options to improve T2D management.
Area of Science:
- Metabolic disorders
- Public health interventions
- Diabetes management
Background:
- The NHS Path to Remission (PtR) program effectively aids weight loss for type 2 diabetes (T2D) patients.
- However, low uptake limits its population-level impact.
Purpose of the Study:
- To evaluate if offering multiple weight loss programs increases participation and persistence.
- To determine if a broader choice of interventions leads to higher T2D remission rates compared to PtR alone.
Main Methods:
- 1788 individuals with recent T2D diagnoses will be randomized to the NewDAWN service or PtR.
- Primary outcome is T2D remission at 12 months; secondary outcomes include weight, HbA1c, and quality of life.
- An internal pilot will assess feasibility based on fidelity, adherence, and weight change.
Main Results:
- Data collection ongoing; results pending.
- The study will assess weight, HbA1c, blood pressure, and patient-reported outcomes.
- Cost-effectiveness analysis of the NewDAWN service will be conducted.
Conclusions:
- Findings will inform the optimal delivery of weight management interventions for T2D.
- The study aims to identify strategies to improve T2D remission rates through increased program accessibility.
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