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Updated: May 12, 2026

Towards Biomimicking Wood: Fabricated Free-standing Films of Nanocellulose, Lignin, and a Synthetic Polycation
Published on: June 17, 2014
Integration of metal-organic frameworks (MOFs) into polyelectrolyte-functionalized nanocellulose polymer: A smart
Zahra Farajzadeh1, Amirhossein Khoshnevisan1, Reza Taghavi1
1Advanced Porous Materials and Energy Technology (APMET) Res. Lab., Department of Chemistry, Iran University of Science and Technology (IUST), PO Box 16846-13114, Tehran, Iran.
Abstract:
Controlled drug delivery offers a viable strategy for cancer treatment by reducing harmful side effects and improving therapeutic effectiveness against tumors. Multifunctional materials are ideal platforms for effective drug delivery systems in cancer treatment. Here, nanocellulose (NC) and microcrystalline cellulose (MCC) were functionalized using a type of ionic liquid (IL, specifically 1-Methyl-3-oxiran-2-ylmethyl-1H-imidazole-3-ium chloride). Subsequently, MCC/IL/ZIF-67 and NC/IL/ZIF-67 composites were obtained via in situ synthesis of ZIF-67. Biocompatible materials, such as cellulose, ionic liquids with functional groups, porosity, and acid sensitivity of ZIF-67, enable the composite to demonstrate a superior doxorubicin (DOX) loading capacity and excellent pH-triggered release compared to most polymeric nanocarriers. The findings of the analysis showed an acceptable drug loading capacity of 32 % and a high drug loading efficiency of 96 %. This result highlights the potential of multifunctional composites as effective drug delivery systems for tumor therapy, making them promising candidates for future therapeutic applications.
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