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A new strain of Fusarium sp. with antimicrobial activity

Xochitl Morales-de la Cruz1, Leonardo Serrano-Márquez1, Guillermo Mendoza2

  • 1Instituto de Ecología, A. C., Red de Biodiversidad y Sistemática. Carretera Antigua a Coatepec No. 351, El Haya, 91073, Xalapa, Veracruz, Mexico.

Microbial Pathogenesis
|August 27, 2025
PubMed

Insights

This study identified Fusarium sp. strain PH130, revealing its potent antimicrobial activity against agricultural and clinical pathogens. Extracts demonstrated significant inhibition of fungi and bacteria, suggesting potential for novel drug discovery.

Area of Science:

  • Microbiology
  • Mycology
  • Biotechnology

Background:

  • Fungi are a rich source of diverse metabolites with pharmaceutical and agricultural applications.
  • Metabolic diversity in fungi drives the search for novel bioactive compounds.
  • Strain PH130, a fungus associated with Lactarius aff. fragilis, was isolated for investigation.

Purpose of the Study:

  • To molecularly identify and phylogenetically place isolated fungal strain PH130.
  • To evaluate the antimicrobial potential of Fusarium sp. strain PH130 extracts against agricultural and clinical pathogens.
  • To assess the preliminary toxicity of the fungal extracts.

Main Methods:

  • Molecular identification using ITS and tef1-α regions.
  • Phylogenetic analysis to determine evolutionary relationships.
  • Antimicrobial activity assays including dual confrontation, determination of Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC).
  • Toxicity assessment using brine shrimp lethality assay (LC50).

Main Results:

  • Strain PH130 was identified as Fusarium sp., evolutionarily related to F. beomiforme.
  • Significant inhibition of phytopathogenic fungi: Acremonium strictum (96%), Colletotrichum asianum (100%), Fusarium oxysporum (75%).
  • Effective activity against clinical yeast Candida tropicalis (MIC/MFC 500 μg/mL).
  • Antimicrobial activity against plant pathogen C. michiganensis (MIC 125 μg/mL, MBC 250 μg/mL) and human pathogens Enterococcus faecalis and Staphylococcus aureus (MIC 250 μg/mL).
  • Moderate to high toxicity observed (LC50 <100-500 μg/mL) against Artemia salina.

Conclusions:

  • Fusarium sp. strain PH130 exhibits significant antimicrobial properties against a range of agricultural and clinical pathogens.
  • The study provides the first report on the extracts of Fusarium sp. strain PH130, highlighting their antimicrobial potential.
  • These findings open avenues for future research into identifying specific bioactive compounds from this fungal strain for drug development.
Keywords:
AntibacterialAntifungalBiological activityFungiSecondary metabolite

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