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Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary

Jun-Zhuo Shi1, Yong-Jian Zhu2, Meng-Jie Zhang3

  • 1School of Pharmacy, Henan University, Kaifeng, China; Anesthesiology Department of Huaihe Hospital, Henan University, Kaifeng, China.

JACC. Basic to Translational Science
|August 27, 2025
PubMed

Keywords:
drug targethypoxanthinemetabolismpulmonary arterial hypertensionvascular remodeling

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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