Related Experiment Video

Updated: Sep 10, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.6K

Severe Group A Streptococcus Infection among Children, France, 2022-2024

Montserrat Sierra Colomina, Alix Flamant, Guillaume Le Balle

    Emerging Infectious Diseases
    |August 27, 2025
    PubMed

    Insights

    Severe Group A Streptococcus infections in children increased in Europe. Treatments like corticosteroids and vasopressors were linked to worse outcomes, highlighting the need for public health collaboration.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Epidemiology

    Background:

    • Group A Streptococcus (GAS) infections have seen a notable increase in Europe since September 2022.
    • Severe GAS infections in children require urgent clinical attention and epidemiological monitoring.

    Purpose of the Study:

    • To investigate the characteristics and outcomes of severe pediatric Group A Streptococcus infections.
    • To identify risk factors associated with severe disease and mortality in children.

    Main Methods:

    • A retrospective and prospective study involving 402 pediatric patients across 34 French hospitals from September 1, 2022, to April 1, 2024.
    • Analysis included clinical presentation, treatment interventions, molecular typing of GAS strains, and patient outcomes (sequelae or death).

    Main Results:

    • The majority of severe GAS cases involved respiratory tract infections (55%), with a lower proportion of skin and soft tissue infections (16%).
    • The overall case-fatality rate was 3.5%. Hydrocortisone, corticosteroid, and vasopressor therapies were significantly associated with major sequelae or death.
    • Emm1 (73.0%) and emm12 (10.8%) were the predominant emm types, with the M1UK clone accounting for 50% of emm1 strains.

    Conclusions:

    • Severe pediatric GAS infections present predominantly with respiratory symptoms and carry a significant risk of adverse outcomes.
    • Specific therapeutic interventions, including corticosteroids and vasopressors, were associated with poorer prognoses, necessitating careful consideration in clinical management.
    • Enhanced collaboration among clinicians, researchers, and public health authorities is crucial to effectively mitigate the impact of GAS on child health.

    Keywords:
    FranceGASStreptococcus pyogenesbacteriagroup A streptococcusinvasive infectionpediatricsrespiratory infectionsstreptococci

    More Related Videos

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

    Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

    Published on: February 9, 2011

    23.1K
    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/4306:06

    Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

    Published on: September 11, 2020

    1.8K

    Related Concept Videos

    Acute Pharyngitis01:30

    Acute Pharyngitis

    Introduction
    Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
    Classification
    Acute pharyngitis can be categorized based on its underlying cause:
    1.5K
    Tonsillitis I: Introduction01:30

    Tonsillitis I: Introduction

    Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
    Etiology
    Three primary contributing factors have been identified.
    538
    Tonsillitis II: Management01:26

    Tonsillitis II: Management

    This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
    174
    Factors Affecting the Risk of Infection01:26

    Factors Affecting the Risk of Infection

    The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
    The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
    12.3K
    Healthcare Associated Infections II: Preventive Measures01:22

    Healthcare Associated Infections II: Preventive Measures

    Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
    The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
    2.8K
    Rheumatic Heart Disease I: Introduction01:23

    Rheumatic Heart Disease I: Introduction

    Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
    38