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Published on: January 7, 2019
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Adherence to evidence-based treatment guidelines for depression: a systematic review
Sophie Dizet1, Emmanuel Haffen2, Hervé Javelot3
1Franche-Comté University UMR 1322 LINC, F-25030 Besançon, France, Expert Centre in Psychopharmacology, Sevrey Public Mental Health Hospital (EPSM71), Sevrey, 71100, France. sophie.dizet@epsm71.fr.
BMC Psychiatry
|August 27, 2025
Summary
Improving adherence to depression treatment guidelines is crucial for better patient outcomes. A multifaceted approach involving clinicians, monitoring, and support enhances guideline adherence.
Area of Science:
- Mental Health
- Clinical Practice Guidelines
- Systematic Review
Background:
- Depression significantly impacts daily life, increasing risks for chronic diseases and mortality.
- Suboptimal adherence to evidence-based treatment guidelines hinders optimal patient outcomes.
- Understanding adherence factors is key to improving depression care.
Purpose of the Study:
- To systematically review adherence to depression treatment guidelines.
- To identify factors influencing adherence to these guidelines.
- To explore strategies for improving guideline adherence in depression management.
Main Methods:
- Searched PubMed, Web of Science, and Cochrane databases.
- Included original trials and studies on treatment guidelines for depressive disorders.
- Excluded reviews, protocols, and studies on other mental disorders.
Main Results:
- 85 studies met inclusion criteria, with some focusing on specific populations (young, perinatal, elderly).
- Limited studies addressed patients with somatic or psychiatric comorbidities or ethnic minorities.
- Variability in adherence rates and measurement methods was observed.
Conclusions:
- Assessing and implementing guideline-concordant care for depression is complex.
- Patient, physician, and guideline-related factors significantly influence adherence.
- Multifaceted implementation strategies, including clinician involvement and organizational support, improve adherence.
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