Regulators of Cancer Progression: Succinylation
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Lysine succinylation, a protein modification, is increasingly linked to cancer progression. Understanding this process and developing targeted drugs could offer new therapeutic strategies for various cancers.
Area Of Science
- Biochemistry
- Oncology
- Molecular Biology
Background
- Lysine succinylation is a recently identified post-translational protein modification.
- Protein post-traditional modifications (PTMs) like acetylation and phosphorylation are known to be associated with cancer.
- Emerging evidence highlights the critical role of succinylation and desuccinylation in the development of lung, prostate, and renal cancers.
Purpose Of The Study
- To review current research on protein succinylation in common cancers.
- To discuss the development of succinylation-targeting drugs.
- To provide insights into molecular mechanisms and therapeutic targets.
Main Methods
- Comprehensive literature review of protein succinylation in cancer.
- Analysis of molecular mechanisms regulating cancer progression via succinylation.
- Identification of key succinylation sites in cancer-related proteins.
Main Results
- Protein succinylation significantly impacts cancer development, particularly in non-histone proteins.
- Succinylome profiling reveals key regulatory roles in various cancer types.
- Progress has been made in identifying and developing drugs targeting succinylation pathways.
Conclusions
- Protein succinylation is a crucial factor in cancer progression.
- Targeting succinylation pathways presents a promising avenue for novel cancer therapies.
- Further research into succinylated proteins and targeted drugs is essential for advancing cancer treatment.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...