Crosstalk Between N6-Methyladenosine and Other Epigenetic Mechanisms in Central Nervous System Development and...

A variety of epigenetic mechanisms-such as DNA methylation, histone alterations, RNA chemical modifications, and regulatory non-coding RNAs-collectively influence gene regulation and cellular processes. Among these, N6-methyladenosine (m⁶A) represents the most widespread internal modification in eukaryotic mRNA, exerting significant influence on RNA metabolic pathways and modulating mRNA function at multiple levels. Studies have shown that m⁶A modification is highly enriched in the brain and regulates central nervous system development and various physiological functions. Recent studies have demonstrated that m⁶A interacts with other epigenetic regulators and triggers epigenetic remodeling, which further affects the development and occurrence of central nervous system diseases. In this review, we provide an up-to-date overview of this emerging research hotspot in biology, with a focus on the interplay between m⁶A and other epigenetic regulators. We highlight their potential roles and regulatory mechanisms in epigenetic reprogramming during central nervous system development and disease, offering insights into potential novel targets and therapeutic strategies for CNS disorders.