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m6A Methylation Modification: Perspectives on the Early Reproduction of Females

Yan Yang1, Zhanhong Zheng1

  • 1College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Biomolecules
|August 28, 2025
PubMed

This review examines the regulatory role of m6A methylation modification in embryo implantation, focusing specifically on its impact on uterine receptivity and decidualization. It offers a comprehensive examination of the essential theoretical research on m6A methylation, clarifying its molecular mechanisms and roles in uterine receptivity and decidualization. Furthermore, this review examined the effects of m6A methylation on endometrial-related diseases and early embryonic development. It synthesizes early findings and recent advancements in m6A methylation studies. Through a comprehensive analysis of relevant studies, this review offers novel insights into the molecular mechanisms underlying embryo implantation and suggests potential strategies for assisted reproductive technologies and the treatment of related disorders, thereby serving as a comprehensive reference for future research in this domain.

Keywords:
decidualizationembryo implantationm6Auterine receptivity

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