Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

2.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.6K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.6K
Language and Cognition01:27

Language and Cognition

438
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
438
Complementation Tests00:49

Complementation Tests

5.1K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suicidality phenotypes reflect both shared and distinct genetic factors.

medRxiv : the preprint server for health sciences·2026
Same author

Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality.

Biomolecules·2026
Same author

Metabolomic Profiling of Extracellular Vesicles Reveals Distinct Metabolic Dysregulation and Treatment-Specific Signatures in Depression.

Biomolecules·2026
Same author

Variants in <i>TPH2</i> and <i>ADARB1</i> genes in completed suicide from the Slovenian population - a follow-up to findings on attempted suicide in the Serbian population.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same author

Epigenetic and Transcriptomic Alterations of Protein Aggregation-Linked Genes in Suicide: A Pilot Study.

Genes·2025
Same author

Epigenomic alterations in psychiatric disorders and glioblastoma.

Epigenomics·2025

Related Experiment Video

Updated: Sep 10, 2025

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.1K

Complement Cascades and Brain Disorders.

Ivana Jovčevska1, Alja Videtič Paska1, Katarina Kouter2

  • 1Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

Biomolecules
|August 28, 2025
PubMed
Summary

The complement system, crucial for immunity, plays a dual role in brain health and disease. Research highlights its involvement in Alzheimer's disease, schizophrenia, and glioma, suggesting therapeutic potential.

Keywords:
complement systemhumoral immunityimmune systeminnate immunityneurodegenerationneurologyoncologypsychiatric disorders

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.3K

Related Experiment Videos

Last Updated: Sep 10, 2025

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.1K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.3K

Area of Science:

  • Neuroscience
  • Immunology
  • Oncology

Background:

  • The complement system is a key part of innate immunity with emerging roles beyond pathogen defense.
  • Its involvement in neurodevelopment, neurodegeneration, and cancer progression is increasingly recognized.

Purpose of the Study:

  • To review the involvement and dysregulation of the complement system in Alzheimer's disease, schizophrenia, and glioma.
  • To summarize the dual protective and pathogenic roles of the complement system in the central nervous system (CNS).

Main Methods:

  • Comprehensive literature review of studies on the complement system in CNS-associated conditions.

Main Results:

  • Complement activation contributes to neuroinflammation, synaptic loss, and neuronal death in Alzheimer's disease.
  • In glioblastoma, complement enhances tumor growth, immune evasion, and therapy resistance.
  • Genetic variations in complement components like C4A are linked to synaptic pruning abnormalities and schizophrenia susceptibility.

Conclusions:

  • The complement system has a complex, dual role in the CNS, acting as both a protector and a mediator of pathology.
  • Understanding its precise functions in neurodegenerative, oncological, and psychiatric disorders is crucial.
  • Targeting the complement system offers potential therapeutic avenues for CNS diseases with further research needed for clinical translation.