Related Experiment Video

Updated: Sep 10, 2025

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein
06:10

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein

Published on: June 18, 2020

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Molecular Duality of OGG1: From Genomic Guardian to Redox-Sensitive Modulator in Diseases

Ranwei Zhong1, Weiran Zhang1, Xiangping Qu1,2,3

  • 1Department of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha 410078, China.

Antioxidants (Basel, Switzerland)
|August 28, 2025
PubMed

Insights

8-oxoguanine DNA glycosylase 1 (OGG1) repairs oxidative DNA damage but can also promote transcription in diseases. This dual role highlights OGG1 as a potential therapeutic target for inflammation and tumors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Oxidative DNA damage is linked to inflammation, cancer, and aging.
  • 8-oxoguanine DNA glycosylase 1 (OGG1) is known for repairing oxidative DNA damage.
  • Emerging evidence suggests OGG1 has additional roles beyond DNA repair.

Purpose of the Study:

  • To review the multifaceted roles of OGG1.
  • To explore OGG1's function as a transcription factor.
  • To identify OGG1 as a therapeutic target for oxidative DNA damage-related diseases.

Main Methods:

  • Literature review of OGG1's functions.
  • Analysis of OGG1's involvement in DNA repair pathways.
  • Investigation of OGG1's transcription factor activity.

Main Results:

  • OGG1 actively repairs oxidative DNA damage.
  • OGG1 exhibits transcription factor activity in certain disease contexts.
  • This dual function influences disease development and progression.

Conclusions:

  • OGG1 plays a critical role in both DNA repair and transcriptional regulation.
  • Dysregulation of OGG1 contributes to diseases like cancer and inflammation.
  • Targeting OGG1 presents a promising therapeutic strategy for related disorders.
Keywords:
8-oxoguanine DNA glycosylase 1DNA damage repairage-related disordersinflammationtumors

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