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Borderline Oxacillin-Resistant Staphylococcus aureus (BORSA) Bacteremia-Case Report
Beverly Buffart1, Philippe Clevenbergh2, Alina Stiuliuc3
1Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium.
Antibiotics (Basel, Switzerland)
|August 28, 2025
Summary
Borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections are rare and difficult to detect. This case highlights challenges in diagnosing and treating BORSA bacteremia, emphasizing the need for improved methods.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Diagnostics
Background:
- Borderline oxacillin-resistant Staphylococcus aureus (BORSA) is a rare phenotype.
- Detection of BORSA is challenging for clinical laboratories.
- Optimal treatment strategies for BORSA infections are not well-established.
Observation:
- A patient with systemic lupus erythematosus developed BORSA bacteremia.
- Antimicrobial susceptibility testing showed conflicting results for oxacillin.
- The patient experienced a delay in appropriate management due to diagnostic challenges.
Findings:
- A rare case of BORSA bacteremia was identified.
- The infection was successfully treated with linezolid and ciprofloxacin.
- Diagnostic discrepancies complicated the initial management.
Implications:
- Improved diagnostic methods for BORSA are needed.
- Further research on BORSA treatment is crucial.
- Clinical awareness of BORSA is essential for timely intervention.
