Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Skeletal Muscle Redox Signaling in Health and Disease: From Molecular Mechanisms to Therapeutic Exercise Strategies.

Antioxidants (Basel, Switzerland)·2026

Same author

Pathophysiological Mechanisms and Clinical Controversies of Sodium-Induced Hypertension: A Multi-Systemic Perspective.

Nutrients·2026

Same author

Influenza Virus-Like Particles Displaying <i>Leishmania donovani</i> Promastigote Surface Antigen Induce Cross-Protective Immunity.

ACS infectious diseases·2026

Same author

Prevalence and Global Distribution of Bacterial Species Associated with Acute Otitis Media in Children: Systematic Review and Meta-Analysis.

Antibiotics (Basel, Switzerland)·2026

Same author

A Narrative Review of In Vivo Studies on the Role of Reactive Oxygen Species in Ovarian Cancer.

Antioxidants (Basel, Switzerland)·2026

Same author

In vitro profiling of Trypanosoma cruzi inhibitors identified from High throughput Screening and application to parasite painting.

International journal for parasitology. Drugs and drug resistance·2026

Same journal

Correction: Coulter et al. OrgTRx: A Platform Developed in Queensland for the Extraction and Visualisation of Antimicrobial Susceptibility Data for the Surveillance of Resistance in Microorganisms. <i>Antibiotics</i> 2026, <i>15</i>, 63.

Antibiotics (Basel, Switzerland)·2026

Same journal

Clinical Outcomes and Safety Profile of Vancomycin in Outpatient Parenteral Antimicrobial Therapy Services: A Systematic Review.

Antibiotics (Basel, Switzerland)·2026

Same journal

Ciprofloxacin-Based Ionic Liquids Increase Mutation Frequency in <i>Escherichia coli</i>.

Antibiotics (Basel, Switzerland)·2026

Same journal

Bacteriophages as Potential Sustainable Alternatives to Antibiotics for Controlling <i>Salmonella</i> in the Poultry Value Chain.

Antibiotics (Basel, Switzerland)·2026

Same journal

Inhibition of Quorum Sensing-Controlled Virulence Factors and Biofilm in <i>Pseudomonas aeruginosa</i> by <i>Piper</i> Species.

Antibiotics (Basel, Switzerland)·2026

Same journal

Antibiotic Use in the Community: Behavioural, Contextual, and System-Level Determinants.

Antibiotics (Basel, Switzerland)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Ivermectin Identified Using a High-Throughput Screening System Exhibits Anti-Clonorchis sinensis Activity in Rats.

Soon-Ok Lee^1,2, Hyeryon Lee³, Ki Back Chu^4,5

¹Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Antibiotics (Basel, Switzerland)

|August 28, 2025

Summary

This summary is machine-generated.

Ivermectin shows promise as a new treatment for clonorchiasis, particularly against the larval stages of the parasite Clonorchis sinensis. This study identified ivermectin as a potential alternative drug for treating this parasitic infection.

Keywords:

Clonorchis sinensis high-throughput screening ivermectin rat

More Related Videos

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Published on: January 31, 2022

Related Experiment Videos

Last Updated: Jun 27, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Culturing and Screening the Plant Parasitic Nematode Ditylenchus dipsaci

Published on: January 31, 2022

Area of Science:

Parasitology
Drug Discovery
Public Health

Background:

Clonorchiasis, caused by the parasite Clonorchis sinensis, is a significant public health issue in East Asia.
Current treatments for clonorchiasis have limitations, necessitating the search for alternative therapeutic agents.

Purpose of the Study:

To identify novel compounds with inhibitory activity against Clonorchis sinensis using high-throughput screening.
To evaluate the efficacy of ivermectin (IVM) as a potential anti-clonorchiasis drug, particularly against larval stages.

Main Methods:

High-throughput screening of 320 compounds to identify inhibitors of Clonorchis sinensis.
In vitro assessment of ivermectin's trematocidal activity against C. sinensis metacercariae (CsMC) and newly excysted juveniles (CsNEJs).
In vivo efficacy study in rats infected with CsMC, with ivermectin treatment targeting larval and adult stages at different post-infection weeks.

Main Results:

Ivermectin demonstrated dose-dependent trematocidal activity against CsMC and CsNEJs in vitro, outperforming praziquantel.
In vivo treatment with ivermectin at 1 week post-infection significantly reduced worm burden in rats, indicating efficacy against larvae.
Parasite-specific IgG and ALT/AST responses in treated rats were similar to the infection control group.

Conclusions:

Ivermectin exhibits significant anti-parasitic effects against Clonorchis sinensis, especially during the larval stages.
Ivermectin represents a potential alternative therapeutic option for treating clonorchiasis, targeting early parasitic development.