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Targeting CEACAM5: Biomarker Characterization and Fluorescent Probe Labeling for Image-Guided Gastric Cancer Surgery.

Serena Martinelli1, Sara Peri2, Cecilia Anceschi2

  • 1Department of Clinical and Experimental Medicine, University of Florence, 50139 Florence, Italy.

Biomedicines
|August 28, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel fluorescent antibody targeting CEACAM5, a key biomarker for gastric cancer (GC). This innovation aims to improve tumor visualization during surgery, enhancing the accuracy of gastric cancer resection.

Keywords:
fluorescent tracersgastric cancerimage-guided surgery

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Area of Science:

  • Oncology
  • Surgical Innovation
  • Biomarker Development

Background:

  • Gastric cancer (GC) presents a significant global health challenge with high mortality rates.
  • Complete surgical resection of GC is often complicated by intraoperative challenges in visualizing tumor margins.
  • Fluorescence-guided surgery (FGS) holds promise for improving tumor detection, but requires selective tumor-targeting agents.

Purpose of the Study:

  • To identify optimal biomarkers for gastric cancer (GC) suitable for fluorescence-guided surgery.
  • To develop a novel fluorescent molecule that selectively targets identified GC biomarkers.
  • To evaluate the efficacy of this fluorescent agent in discriminating tumor tissue from healthy tissue.

Main Methods:

  • Examined expression of CEACAM5 and CLDN4 in GC cell lines.
  • Performed immunohistochemistry on patient tumor and healthy tissues.
  • Developed and tested a CEACAM5-targeting fluorescent antibody on cell lines and patient tissues.

Main Results:

  • Identified CEACAM5 as a highly suitable biomarker for GC.
  • Developed a specific fluorescent antibody targeting CEACAM5.
  • Demonstrated optimal binding specificity and discrimination between GC and healthy tissues.

Conclusions:

  • The developed CEACAM5-specific fluorescent antibody shows potential as a tumor-specific imaging agent.
  • Further in vivo validation is warranted.
  • This agent could significantly improve the accuracy of complete tumor resection in gastric cancer surgery.