Artificial Intelligence and Its Role in Predicting Periprosthetic Joint Infections

Diana Elena Vulpe1,2, Catalin Anghel3, Cristian Scheau1,4

  • 1The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Biomedicines
|August 28, 2025
PubMed

Insights

Artificial intelligence (AI) shows promise in improving early diagnosis of periprosthetic joint infections (PJIs) after joint replacement. This review explores AI

Area of Science:

  • Orthopedic surgery
  • Medical informatics
  • Artificial intelligence in healthcare

Background:

  • Periprosthetic joint infections (PJIs) are a major complication of total joint replacement, impacting patient quality of life and healthcare expenses.
  • Early and accurate PJI diagnosis is crucial but challenging with traditional methods.
  • Artificial intelligence (AI) offers advanced data analysis capabilities for healthcare applications.

Purpose of the Study:

  • To review the current applications of AI in predicting PJIs.
  • To explore the types of AI algorithms used and their performance.
  • To identify limitations and challenges in implementing AI for PJI diagnosis.

Main Methods:

  • Literature review of studies utilizing AI for PJI prediction.
  • Analysis of AI algorithm types and reported performance metrics.
  • Discussion of clinical implementation challenges.

Main Results:

  • AI algorithms demonstrate potential for enhancing the assessment of risk factors and prediction of complications like PJIs.
  • Various AI algorithms are being explored, with performance metrics varying across studies.
  • Significant challenges and limitations exist for widespread clinical adoption.

Conclusions:

  • AI holds promise for improving early PJI detection and management.
  • Further research and validation are needed to overcome implementation barriers.
  • AI integration could lead to more efficient and accurate PJI diagnostics.