Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Direct Motor Pathways01:11

Direct Motor Pathways

4.7K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.7K
Indirect Motor Pathways01:22

Indirect Motor Pathways

3.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Müller Glial Activation and Retinal Ganglion Cell Synaptic Dysfunction in APP/PS1 Mice.

Cells·2026
Same author

A gain-of-function Retsat variant from high-altitude adaptation promotes myelination via a neuronal dihydroretinoic acid-RXR-γ pathway.

Neuron·2026
Same author

Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease.

Neuroscience bulletin·2026
Same author

Bulk-based nonlinear pulse compression of 30 mJ and 150 W pulses of an ultrafast thin-disk amplifier.

Optics express·2026
Same author

TDP-43 Mediates Autophagic Degradation of Yki by Stabilizing Ref(2)P in Drosophila.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Production of ETP-Type (Epipolythiodioxopiperazine) Mycotoxins in Clinical Fungal Isolates.

Journal of natural products·2026

Related Experiment Video

Updated: May 5, 2026

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

11.5K

Red Nucleus Excitatory Neurons Initiate Directional Motor Movement in Mice.

Chenzhao He1, Guibo Qi1, Xin He1

  • 1Department of Anatomy and Histology Embryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Biomedicines
|August 28, 2025
PubMed
Summary

The red nucleus (RN) controls directional movement. Specific RN neurons activate during turning, and manipulating them causally affects ipsilateral limb control, revealing its role in lateralized motor functions.

Keywords:
anterogradeexcitatory neuronslateralized movementred nucleus

More Related Videos

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

18.6K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.4K

Related Experiment Videos

Last Updated: May 5, 2026

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

11.5K
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

18.6K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.4K

Area of Science:

  • Neuroscience
  • Motor Control
  • Midbrain Function

Background:

  • The red nucleus (RN) is a midbrain structure involved in motor coordination.
  • Its precise role in directional movement control is not well understood.

Purpose of the Study:

  • To investigate the function and mechanism of red nucleus neurons in directional movement control.
  • To elucidate the role of the RN in lateralized motor functions.

Main Methods:

  • Stereotactic brain injections
  • Fiber photometry and in vivo electrophysiological recordings
  • Optogenetic manipulation and anterograde trans-synaptic tracing in mice

Main Results:

  • Distinct RN neuronal ensembles show direction-selective activity, preferentially activating during ipsilateral turning.
  • Optogenetic activation of RN glutamatergic neurons facilitates ipsilateral turning.
  • Inhibition of RN neurons impairs turning execution, establishing a causal link.

Conclusions:

  • The red nucleus is a specialized hub for mediating lateralized movements.
  • Findings provide a framework for understanding asymmetric motor control.
  • This research opens avenues for treating motor disorders affecting movement control.