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Related Experiment Video

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High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
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Shear Wave Elastography for Distinguishing Cervical Lymph Node Malignancy: A Prospective, Observational Study.

Dragos A Termure1, Manuela Lenghel2, Mindra E Badea3

  • 1Department of Maxillofacial Surgery and Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania.

Biomedicines
|August 28, 2025
PubMed
Summary

Shear wave elastography (SWE) can differentiate benign from malignant cervical lymph nodes. This ultrasound technique shows promise for preoperative assessment of nodal status in head and neck cancers.

Keywords:
cervicallymph nodelymphomametastasisshear wave elastography

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Area of Science:

  • Medical Imaging
  • Oncology
  • Ultrasound Technology

Background:

  • Distinguishing benign from malignant cervical lymph nodes is clinically significant.
  • Cervical lymphadenopathy can result from lymphomas or solid tumor metastases.
  • Accurate preoperative nodal staging is crucial for treatment planning.

Purpose of the Study:

  • To evaluate the efficacy of shear wave elastography (SWE) in differentiating lymphomas and solid tumor metastases in cervical lymph nodes.
  • To assess the quantitative stiffness measurements provided by SWE for nodal characterization.

Main Methods:

  • Prospective, observational, single-center study involving adults with suspicious cervical lymph nodes.
  • Conventional ultrasound and shear wave elastography (SWE) with quantitative stiffness assessment (kPa).
  • Pathology examination served as the gold standard for confirmation; statistical analysis included logistic regression.

Main Results:

  • Maximum shear wave velocity (SWV) was lower in benign pathologies (35 kPa) compared to lymphoma (40 kPa) and metastases (50 kPa).
  • Higher prevalence of squamous cell carcinoma and distant metastases observed in men.
  • Each 1 kPa increase in SWE measurement correlated with a 3% rise in the risk of metastatic adenopathy.

Conclusions:

  • Shear wave elastography (SWE) demonstrates significant potential for the preoperative assessment of nodal status.
  • SWE can aid in distinguishing between benign and malignant cervical lymph nodes.
  • This technique is valuable for managing malignancies affecting the head and neck, thyroid, and other regions.