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Chlamydia trachomatis-Specific Antibodies and In Vitro Fertilization Outcome
Natasa Djordjevic1, Ana Todorovic2, Predrag Sazdanovic3,4
1Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Biomedicines
|August 28, 2025
Summary
Chlamydia trachomatis infection markers in follicular fluid and serum are linked to lower in vitro fertilization (IVF) success rates. Negative antibody presence in follicular fluid correlated with higher implantation rates.
Area of Science:
- Reproductive Medicine
- Infectious Diseases
- Immunology
Background:
- * *Chlamydia trachomatis* (CT) infection is a known factor impacting female fertility.
- * Understanding CT's role in in vitro fertilization (IVF) outcomes is crucial for improving success rates.
Purpose of the Study:
- * To evaluate the association between serological and follicular fluid markers of CT infection and IVF success.
- * To investigate the impact of anti-major outer membrane protein (anti-MOMP) IgG and IgA on IVF outcomes.
Main Methods:
- * Prospective multicenter cohort study of female patients undergoing IVF in Serbia.
- * Serum and follicular fluid samples collected during IVF procedures.
- * Anti-MOMP IgG and IgA antibodies detected using Enzyme-Linked Immunosorbent Assay (ELISA).
Main Results:
- * Significantly higher embryo implantation rates observed in patients negative for follicular fluid antibodies (OR: 5.254).
- * Trend towards increased IVF failure risk in patients positive for follicular fluid or serum CT antibodies.
- * Advanced maternal age correlated with lower odds of successful implantation, biochemical pregnancy, and live birth.
Conclusions:
- * Presence of chlamydial anti-MOMP IgG and IgA in serum/follicular fluid may indicate reduced IVF success.
- * Advanced maternal age is a significant risk factor for IVF failure.
- * Further research into CT infection markers could optimize fertility treatments.
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