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Related Concept Videos

Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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Related Experiment Video

Updated: Jun 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Hydrogels Modulating the Microbiome: Therapies for Tissue Regeneration with Infection Control.

Germán Reynaldo Jiménez-Gastelum1, Carlos Esteban Villegas-Mercado2, Juan Luis Cota-Quintero1

  • 1Faculty of Biology, Autonomous University of Sinaloa, Culiacan PC 80013, Mexico.

Gels (Basel, Switzerland)
|August 28, 2025
PubMed
Summary

Functionalized hydrogels can modulate the microbiome to improve tissue regeneration and control infections. These advanced materials deliver beneficial microbes and antimicrobials, promoting healing and immune balance for better therapeutic outcomes.

Keywords:
Hydrogel-based scaffoldsHydrogelsinfection controlmicrobiomemicrobiome modulationtissue regeneration

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Regenerative Medicine

Background:

  • The skin and gut microbiomes are vital for tissue homeostasis, immune regulation, and healing.
  • Microbial imbalances contribute to impaired regeneration and increased infection risk in conditions like chronic wounds.

Purpose of the Study:

  • To review the role of functionalized hydrogels in microbiome modulation for therapeutic applications.
  • To explore hydrogel-based delivery of probiotics, prebiotics, and antimicrobials for tissue regeneration and infection control.

Main Methods:

  • Review of literature on hydrogel functionalization and microbiome modulation.
  • Analysis of hydrogel systems for delivering probiotics (e.g., *Lactobacillus plantarum*, *Prevotella histicola*).
  • Examination of hydrogels functionalized with antimicrobial agents (e.g., silver nanoparticles, nitric oxide donors, bacteriocins).

Main Results:

  • Hydrogels enhance viability and targeted delivery of beneficial bacteria, promoting immune tolerance.
  • Functionalized hydrogels effectively disrupt biofilms and clear pathogens.
  • These systems promote pro-regenerative immune responses, including M2 macrophage polarization and regulatory T cell induction.

Conclusions:

  • Functionalized hydrogels offer a versatile platform for microbiome-based therapies in tissue regeneration and infection management.
  • Advanced hydrogel technologies like 3D bioprinting and responsive materials enhance clinical applicability.