Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electrical Stimulation-Induced Modulation of Small Extracellular Vesicles in Regenerative Therapy.

Tissue engineering and regenerative medicine·2026

Same author

Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.

Cardiovascular diabetology·2026

Same author

Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration.

Biomaterials research·2026

Same author

Automation-assisted human skin-on-a-chip for modeling ultraviolet-induced injury and evaluating photoprotective and regenerative modalities.

Lab on a chip·2026

Same author

Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation.

Tissue engineering and regenerative medicine·2026

Same author

Sprayable, crosslinker-free, and in situ-forming Schiff-based hydrogels based on oxidized sodium alginate and carbohydrazide-modified gelatin for rapid hemostasis.

Carbohydrate polymers·2025

Search research articles

Related Experiment Video

Updated: Sep 10, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogel-Based Nitric Oxide Delivery Systems for Enhanced Wound Healing.

Tae-Hyun Heo¹, Hye-Jeong Jang¹, Gun-Jae Jeong²

¹Department of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Republic of Korea.

Gels (Basel, Switzerland)

|August 28, 2025

Summary

Hydrogels can deliver nitric oxide (NO) to chronic wounds, scavenging reactive oxygen species (ROS) and promoting healing. This approach enhances angiogenesis and regeneration in hypoxic wound environments.

Keywords:

angiogenesis hydrogel nitric oxide reactive oxygen species wound healing

More Related Videos

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Sep 10, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Chronic wounds exhibit hypoxic physiology, where oxidative stress from reactive oxygen species (ROS) hinders regeneration.
Nitric oxide (NO) is a crucial gasotransmitter regulating hypoxia and signaling pathways in wound healing.
Hydrogels offer a promising platform for delivering therapeutic agents to wound sites.

Purpose of the Study:

To review hydrogel-based strategies for stable delivery of nitric oxide (NO) to chronic wound environments.
To elucidate the role of NO in angiogenesis and its impact on the wound healing cascade.
To explore the integration of NO donors within hydrogel matrices for enhanced therapeutic outcomes.

Main Methods:

Review of literature on hydrogel properties, NO donors, and their application in wound healing.
Analysis of the physiological effects of ROS and NO in hypoxic wound conditions.
Examination of controlled and sustained release mechanisms of NO from hydrogel carriers.

Main Results:

Hydrogels provide biocompatible and hydrophilic matrices for NO donor incorporation.
Controlled NO release from hydrogels can modulate ROS levels and promote angiogenesis.
Various NO donors can be effectively integrated into hydrogel formulations for therapeutic delivery.

Conclusions:

Hydrogel-based NO delivery systems represent a viable strategy for accelerating chronic wound healing.
Functional hydrogels incorporating NO donors offer significant potential for regenerative treatments.
Further research into novel hydrogel designs can optimize NO-based wound therapies.