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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
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Related Experiment Video

Updated: Sep 10, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Impact of Chromosomal Structural Rearrangements on IVF Laboratory Outcomes in PGT-SR Cycles: A Propensity Score

Daria Marzanati1,2, Sara D'Alessandro3, Davide Gentilini1,4

  • 1Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.

Life (Basel, Switzerland)
|August 28, 2025
PubMed
Summary

Patients undergoing preimplantation genetic testing for structural rearrangements (PGT-SR) have fewer blastocysts for biopsy. Reciprocal translocations significantly reduce the rate of normal/balanced blastocysts, impacting treatment success.

Keywords:
PGT-SRblastocyst development ratereciprocal translocationstructural rearrangements

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Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
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Area of Science:

  • Reproductive Medicine
  • Human Genetics
  • Assisted Reproductive Technologies

Background:

  • Chromosomal structural rearrangements (SR) can lead to unbalanced embryos.
  • Assisted reproduction technologies (ARTs) with preimplantation genetic testing for structural rearrangements (PGT-SR) can identify chromosomally normal/balanced embryos.
  • Limited data exists on IVF laboratory outcomes for PGT-SR.

Purpose of the Study:

  • To compare IVF laboratory outcomes between cycles with PGT-SR and PGT-A.
  • To investigate factors influencing normal/balanced blastocyst rates in PGT-SR cycles.

Main Methods:

  • Retrospective cohort study of 548 ART cycles (129 PGT-SR, 419 PGT-A).
  • Propensity score matching and logistic regression for outcome comparison.
  • Generalized linear mixed-effects model to assess SR type and carrier gender effects.

Main Results:

  • Fertilization rates were similar between PGT-SR and PGT-A groups.
  • PGT-SR cycles showed significantly lower blastocyst development (36.7% vs. 47.1%) and top-quality blastocyst rates (9.6% vs. 21.1%).
  • Non-reciprocal SRs yielded higher normal/balanced blastocyst rates (89.9%) than reciprocal translocations (45.7%).

Conclusions:

  • Patients undergoing PGT-SR produce fewer blastocysts for biopsy.
  • Reciprocal translocations significantly reduce the availability of normal/balanced blastocysts for transfer.
  • Personalized counseling is crucial for managing patient expectations and clinical decision-making in PGT-SR cases.