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Updated: Sep 10, 2025

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Autoimmune Gastritis and Helicobacter pylori Infection: Molecular Mechanisms of Relationship
Dmitry S Bordin1,2,3, Maria A Livzan4, Sergei I Mozgovoi5
1A. S. Loginov Moscow Clinical Scientific Center, Department of Pathology of the Pancreas, Bile Ducts and Upper Digestive Tract, 111123 Moscow, Russia.
Abstract:
Helicobacter pylori (H. pylori) infection and autoimmune inflammation of the gastric mucosa are recognized as the leading etiological factors of chronic atrophic gastritis. The mechanisms of atrophy formation and progression with the risk of gastric cancer development are heterogeneous, which requires a deeper study of the molecular mechanisms of relationship, peculiarities of the course of autoimmune gastritis both in combination with H. pylori and after eradication, as well as without H. pylori infection (naïve AIG). This article presents the specific molecular and cellular patterns in the formation of these related conditions.
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