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Updated: Sep 10, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
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BRD4 Mediates Transforming Growth Factor-β-Induced Smooth Muscle Cell Differentiation from Mesenchymal Progenitor

Ayobami Olajuyin1, Venkatakirankumar Mandlem1, Christudas Sunil1

  • 1Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.

International Journal of Molecular Sciences
|August 28, 2025
PubMed
Summary

Bromodomain-containing protein 4 (BRD4) is a novel regulator of smooth muscle cell (SMC) differentiation. It controls SMC marker expression by modulating TAZ and myocardin, crucial for blood vessel development.

Keywords:
BRD4TAZTGF-βdifferentiationmyocardinsmooth muscle cell

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