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Pre-Exposure Prophylaxis Uptake, Implementation and Barriers in Africa: A Scoping Review Protocol
Silingene Joyce Ngcobo1, Tracy Zhandire1
1Discipline of Nursing and Public Health, University of KwaZulu-Natal, Durban 4001, South Africa.
This scoping review examines pre-exposure prophylaxis (PrEP) uptake in Africa, identifying barriers and facilitators to improve consistent use. Findings will guide strategies to enhance HIV prevention across diverse African settings.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Global Health Security
Background:
- Africa faces a high burden of HIV, with suboptimal uptake of pre-exposure prophylaxis (PrEP), a highly effective HIV prevention method.
- Despite PrEP's proven efficacy (>90%), consistent use remains a challenge across many African countries.
Purpose of the Study:
- To systematically map literature on PrEP uptake and implementation in Africa.
- To identify barriers, facilitators, target populations, and policy approaches for PrEP delivery.
- To inform evidence-based strategies for enhancing PrEP uptake and scaling up HIV prevention.
Main Methods:
- A scoping review following the Arksey and O'Malley framework, refined by Levac et al.
- Comprehensive searches of electronic databases, grey literature, and official reports.
- Thematic synthesis of data to identify trends, gaps, and contextual variations.
Main Results:
- Mapping of current PrEP implementation landscape in Africa.
- Identification of key barriers and facilitators influencing PrEP access and adherence.
- Analysis of contextual variations and policy gaps across diverse African settings.
Conclusions:
- A comprehensive overview of PrEP implementation in Africa is provided.
- Research trends, contextual variations, and service delivery gaps are highlighted.
- Findings will inform future strategies to enhance PrEP uptake and support HIV prevention efforts.
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