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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Cellular Rejection Post-Cardiac Transplantation: A 13-Year Single Unicentric Study.

Gabriela Patrichi1,2, Catalin-Bogdan Satala3,4, Andrei Ionut Patrichi5

  • 1Molecular and Cell Biology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Targu Mures, Romania.

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Summary
This summary is machine-generated.

Cardiac transplant rejection is a risk factor for patient outcomes. This study found most patients had no rejection, but non-rejection lesions were common, suggesting a need to refine rejection grading criteria.

Keywords:
ACRAMRcardiac transplantation

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Area of Science:

  • Cardiology
  • Transplantation Immunology
  • Pathology

Background:

  • Cardiac transplantation is the primary treatment for end-stage heart failure.
  • Cellular rejection post-transplant significantly impacts patient morbidity and mortality.
  • Understanding clinicopathologic factors in rejection mechanisms is crucial.

Purpose of the Study:

  • To evaluate clinicopathologic factors influencing cardiac allograft rejection.
  • To analyze histopathologic findings in post-transplant myocardial biopsies.
  • To assess the prevalence and characteristics of rejection versus non-rejection lesions.

Main Methods:

  • Retrospective analysis of 146 cardiac transplant recipients.
  • Evaluation of myocardial function and structure via endomyocardial biopsy.
  • Classification of acute cellular rejection (ACR) and antibody-mediated rejection (AMR) using ISHLT criteria.

Main Results:

  • Most patients (82.2%) showed no rejection (ISHLT score 0).
  • Non-rejection-related lesions were observed in 45.2% of cases.
  • Ischemia-reperfusion lesions occurred in 25.3% of patients; mild inflammatory changes were frequent (71.9%).

Conclusions:

  • While overt rejection is infrequent, non-rejection histopathologic changes are prevalent.
  • Current rejection grading criteria may require adjustment to account for non-rejection lesions.
  • Mononuclear inflammatory infiltrates, though often mild, are key indicators associated with rejection phenomena.